I studied Bioinformatics as I wanted to crack the code of the genomic content which is represented using only 4 letters. This led me to working with various animal models such as plants, insects and humans. I’ve performed various types of bioinformatic analyses which includes genome assembly, transcriptomic analyses and genomic analyses. I’ve mainly worked on different types of sequence analyses and now I’m trying to look into evolution with my previously acquired skills.
I’m working on “Neo-sex chromosome evolution and dosage compensation in morabine grasshoppers”. The main goal is to characterise the extent of recombination suppression across Vandiemenella viatica species nascent sex chromosomes, and to determine whether chromosome-wide dosage compensation or dosage-sensitive genes contribute to the maintenance of gene dosage on degenerate sex chromosomes and also how fast the Neo-Y degenerates after recombination suppression.
Publications and preprints
Desai, S.S., Rao, R.K., Jain, A., Bawa, P.S., Dutta, P., Atre, G., Subhash, A., Rao, V.U.S., Jayaprasad, S., Srinivasan, S. & Choudhary, B. (2021). Multidimensional mutational profiling of the Indian HNSCC sub-population provides IRAK1, a novel driver gene and potential druggable target. Frontiers in Oncology 11: 723162. doi: 10.3389/fonc.2021.723162External link
Chakraborty, M., Ramaiah, A., Adolfi, A., Halas, P., Kaduskar, B., Ngo, L.T., Jayaprasad, S., Paul, K., Whadgar, S., Srinivasan, S., Subramani, S., Bier, E., James, A.A. & Emerson, J.J. (2021). Hidden genomic features of an invasive malaria vector, Anopheles stephensi, revealed by a chromosome-level genome assembly. BMC Biology 19: 28. doi: 10.1186/s12915-021-00963-zExternal link
Chida, A.R., Ravi, S., Jayaprasad, S., Paul, K., Saha, J., Suresh, C., Whadgar, S., Kumar, N., Rao, K.R., Ghosh, C., Choudhary, B., Subramani, S. & Srinivasan, S. (2020). A near-chromosome level genome assembly of Anopheles stephensi. Frontiers in Genetics 11: 565626. doi: 10.3389/fgene.2020.565626External link
Deb, S., Jayaprasad, S., Ravi, S., Rao, K.R., Whadgar, S., Hariharan, N., Dixit, S., Sunil, M., Choudhary, B., Stevanato, P., Ramireddy, E. & Srinivasan, S. (2020). Classification of grain amaranths using chromosome-level genome assembly of ramdana, A. hypochondriacus. Frontiers in Plant Science 11: 579529. doi: 10.3389/fpls.2020.579529External link
Viswanathan, V., Narjala, A., Ravichandran, A., Jayaprasad, S. & Siddaramappa, S. (2017). Evolutionary genomics of an ancient prophage of the order Sphingomonadales. Genome Biology and Evolution 9: 646-658. doi: 10.1093/gbe/evx024External link